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Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design

Berry, David J.; Steed, Jonathan W.

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Authors

David J. Berry



Abstract

As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important to global health initiatives. Improvements in the physical properties of Active Pharmaceutical Ingredients (APIs), without changes in the covalent chemistry, have long been possible through the application of binary component solids. This was first achieved through the use of pharmaceutical salts, within the last 10–15 years with cocrystals and more recently coamorphous systems have also been consciously applied to this problem. In order to rationally discover the best multicomponent phase for drug development, intermolecular interactions need to be considered at all stages of the process. This review highlights the current thinking in this area and the state of the art in: pharmaceutical multicomponent phase design, the intermolecular interactions in these phases, the implications of these interactions on the material properties and the pharmacokinetics in a patient.

Citation

Berry, D. J., & Steed, J. W. (2017). Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design. Advanced Drug Delivery Reviews, 117, 3-24. https://doi.org/10.1016/j.addr.2017.03.003

Journal Article Type Article
Acceptance Date Mar 21, 2017
Online Publication Date Mar 23, 2017
Publication Date Aug 1, 2017
Deposit Date Mar 27, 2017
Publicly Available Date Mar 23, 2018
Journal Advanced Drug Delivery Reviews
Print ISSN 0169-409X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 117
Pages 3-24
DOI https://doi.org/10.1016/j.addr.2017.03.003

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