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Pharmaceutical cocrystals, salts and multicomponent systems ; intermolecular interactions and property based design.

Berry, David J. and Steed, Jonathan W. (2017) 'Pharmaceutical cocrystals, salts and multicomponent systems ; intermolecular interactions and property based design.', Advanced drug delivery reviews., 117 . pp. 3-24.


As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important to global health initiatives. Improvements in the physical properties of Active Pharmaceutical Ingredients (APIs), without changes in the covalent chemistry, have long been possible through the application of binary component solids. This was first achieved through the use of pharmaceutical salts, within the last 10–15 years with cocrystals and more recently coamorphous systems have also been consciously applied to this problem. In order to rationally discover the best multicomponent phase for drug development, intermolecular interactions need to be considered at all stages of the process. This review highlights the current thinking in this area and the state of the art in: pharmaceutical multicomponent phase design, the intermolecular interactions in these phases, the implications of these interactions on the material properties and the pharmacokinetics in a patient.

Item Type:Article
Full text:(AM) Accepted Manuscript
Available under License - Creative Commons Attribution Non-commercial No Derivatives.
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Publisher statement:© 2017 This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Date accepted:21 March 2017
Date deposited:27 March 2017
Date of first online publication:23 March 2017
Date first made open access:23 March 2018

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