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Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past

Olivieri, A.; Sidore, C.; Achilli, A.; Angius, A.; Posth, C.; Furtwängler, A.; Brandini, S.; Rosario Capodiferro, M.; Gandini, F.; Zoledziewska, M.; Pitzalis, M.; Maschio, A.; Busonero, F.; Lai, L.; Skeates, R.; Gradoli, M.G.; Beckett, J.; Marongiu, M.; Mazzarello, V.; Marongiu, P.; Rubino, S.; Rito, T.; Macaulay, V.; Semino, O.; Pala, M.; Abecasis, G.R.; Schlessinger, D.; Conde-Sousa, E.; Soares, P.; Richards, M.B.; Cucca, F.; Torroni, A.

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Authors

A. Olivieri

C. Sidore

A. Achilli

A. Angius

C. Posth

A. Furtwängler

S. Brandini

M. Rosario Capodiferro

F. Gandini

M. Zoledziewska

M. Pitzalis

A. Maschio

F. Busonero

L. Lai

M.G. Gradoli

J. Beckett

M. Marongiu

V. Mazzarello

P. Marongiu

S. Rubino

T. Rito

V. Macaulay

O. Semino

M. Pala

G.R. Abecasis

D. Schlessinger

E. Conde-Sousa

P. Soares

M.B. Richards

F. Cucca

A. Torroni



Abstract

Sardinians are “outliers” in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimum and maximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.

Citation

Olivieri, A., Sidore, C., Achilli, A., Angius, A., Posth, C., Furtwängler, A., …Torroni, A. (2017). Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past. Molecular Biology and Evolution, 34(5), 1230-1239. https://doi.org/10.1093/molbev/msx082

Journal Article Type Article
Acceptance Date Feb 3, 2017
Online Publication Date Feb 8, 2017
Publication Date May 1, 2017
Deposit Date May 30, 2017
Publicly Available Date Mar 29, 2024
Journal Molecular Biology and Evolution
Print ISSN 0737-4038
Electronic ISSN 1537-1719
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 34
Issue 5
Pages 1230-1239
DOI https://doi.org/10.1093/molbev/msx082

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Copyright Statement
© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com






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