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Systems modelling ageing : from single senescent cells to simple multi-cellular models.

Martinez Guimera, Alvaro and Welsh, Ciaran and Dalle Pezze, Piero and Fullard, Nicola and Nelson, Glyn and Roger, Mathilde F. and Przyborski, Stefan A. and Shanley, Daryl P. (2017) 'Systems modelling ageing : from single senescent cells to simple multi-cellular models.', Essays in biochemistry., 61 (3). pp. 369-377.

Abstract

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1042/EBC20160087
Publisher statement:© 2017 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Date accepted:25 May 2017
Date deposited:25 July 2017
Date of first online publication:11 July 2017
Date first made open access:25 July 2017

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