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Nucleophilic Trifluoromethylation of Electron-Deficient Arenes

Pike, Jack A.; Walton, James William

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Authors

Jack A. Pike



Abstract

A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion of nitroarenes into 1,2-trifluoromethylated nitroarenes, via a C‒H activation pathway. Furthermore, a substitution of nitroarenes to trifluoromethyl arenes is also presented.

Citation

Pike, J. A., & Walton, J. W. (2017). Nucleophilic Trifluoromethylation of Electron-Deficient Arenes. Chemical Communications, 53(71), https://doi.org/10.1039/c7cc05415g

Journal Article Type Article
Acceptance Date Aug 14, 2017
Online Publication Date Aug 14, 2017
Publication Date Aug 14, 2017
Deposit Date Aug 16, 2017
Publicly Available Date Aug 14, 2018
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 53
Issue 71
DOI https://doi.org/10.1039/c7cc05415g

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Accepted Journal Article (Supplementary information) (680 Kb)
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Copyright Statement
Supplementary information





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