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Repurposing as a strategy for the discovery of new anti-leishmanials : the-state-of-the-art.

Charlton, Rebecca and Rossi-Bergmann, Bartira and Denny, Paul W. and Steel, Patrick G. (2018) 'Repurposing as a strategy for the discovery of new anti-leishmanials : the-state-of-the-art.', Parasitology., 145 (2). pp. 219-236.

Abstract

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.

Item Type:Article
Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution.
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Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution.
Download PDF
(804Kb)
Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1017/S0031182017000993
Publisher statement:© Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the CreativeCommons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date accepted:25 May 2017
Date deposited:22 August 2017
Date of first online publication:14 August 2017
Date first made open access:No date available

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