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Nuclear pore complex tethers to the cytoskeleton.

Goldberg, Martin W. (2017) 'Nuclear pore complex tethers to the cytoskeleton.', Seminars in cell & developmental biology., 68 . pp. 52-58.


The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.

Item Type:Article
Full text:(AM) Accepted Manuscript
Available under License - Creative Commons Attribution Non-commercial No Derivatives.
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Publisher statement:© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Date accepted:23 June 2017
Date deposited:06 September 2017
Date of first online publication:01 July 2017
Date first made open access:01 July 2018

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