Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Nicholson, CE; Chen, C; Mendis, B; Cooper, SJ

doi:10.1021/cg101200f

Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology

Nicholson, CE; Chen, C; Mendis, B; Cooper, SJ

Authors

CE Nicholson

C Chen

Dr Buddhika Mendis b.g.mendis@durham.ac.uk
Associate Professor

Professor Sharon Cooper sharon.cooper@durham.ac.uk
Professor

Abstract

Thermodynamic control of crystallization has been achieved to produce stable polymorphs directly by using three-dimensional (3D) nanoconfinement in microemulsions. The theoretical basis for thermodynamic control of crystallization using 3D nanoconfinement is outlined. The generality of our approach is demonstrated by crystallizing the stable polymorph of three “problem” compounds from microemulsions under conditions yielding metastable forms in bulk solution.

Citation

Nicholson, C., Chen, C., Mendis, B., & Cooper, S. (2011). Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology. Crystal Growth and Design, 11(2), 363-366. https://doi.org/10.1021/cg101200f

Journal Article Type	Article
Online Publication Date	Jan 5, 2011
Publication Date	Jan 5, 2011
Deposit Date	Jan 30, 2012
Publicly Available Date	Sep 12, 2017
Journal	Crystal Growth and Design
Print ISSN	1528-7483
Electronic ISSN	1528-7505
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	11
Issue	2
Pages	363-366
DOI	https://doi.org/10.1021/cg101200f

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal growth & design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/cg101200f