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The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.

Cardew, E.M. and Verlinde, C.L.J.M. and Pohl, E. (2018) 'The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.', Parasitology., 145 (2). pp. 210-218.

Abstract

The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1017/s0031182017001901
Publisher statement:© Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date accepted:25 August 2017
Date deposited:12 September 2017
Date of first online publication:01 December 2017
Date first made open access:No date available

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