Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases

Goodwin, Melissa J.; Steed, Benjamin W.; Yufit, Dmitry S.; Musa, Osama M.; Berry, David J.; Steed, Jonathan W.

doi:10.1021/acs.cgd.7b01103

Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases

Goodwin, Melissa J.; Steed, Benjamin W.; Yufit, Dmitry S.; Musa, Osama M.; Berry, David J.; Steed, Jonathan W.

Authors

Melissa J. Goodwin

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Dmitry S. Yufit

Osama M. Musa

David J. Berry

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Abstract

Povidone-iodine is a widely used antiseptic and on the World Health Organization’s List of Essential Medicines. We report the X-ray crystal structure of a two-monomer unit model compound showing that the structure of povidone-iodine comprises protonated pyrrolidone units linked by intermolecular hydrogen bonds along with triiodide anions. We also report an unusual example of a system exhibiting both a cocrystal and coamorphous form in a halogen bonded lactam model compound with diiodotetrafluorobenzene.

Citation

Goodwin, M. J., Steed, B. W., Yufit, D. S., Musa, O. M., Berry, D. J., & Steed, J. W. (2017). Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases. Crystal Growth and Design, 17(10), 5552-5558. https://doi.org/10.1021/acs.cgd.7b01103

Journal Article Type	Article
Acceptance Date	Sep 13, 2017
Online Publication Date	Sep 18, 2017
Publication Date	Oct 4, 2017
Deposit Date	Oct 13, 2017
Publicly Available Date	Sep 18, 2018
Journal	Crystal Growth and Design
Print ISSN	1528-7483
Electronic ISSN	1528-7505
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	17
Issue	10
Pages	5552-5558
DOI	https://doi.org/10.1021/acs.cgd.7b01103

Files

Accepted Journal Article (1.9 Mb)
PDF

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01103.