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Durham Research Online
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Halogen and hydrogen bonding in povidone-iodine and related co-phases.

Goodwin, Melissa J. and Steed, Benjamin W. and Yufit, Dmitry S. and Musa, Osama M. and Berry, David J. and Steed, Jonathan W. (2017) 'Halogen and hydrogen bonding in povidone-iodine and related co-phases.', Crystal growth & design., 17 (10). pp. 5552-5558.

Abstract

Povidone-iodine is a widely used antiseptic and on the World Health Organization’s List of Essential Medicines. We report the X-ray crystal structure of a two-monomer unit model compound showing that the structure of povidone-iodine comprises protonated pyrrolidone units linked by intermolecular hydrogen bonds along with triiodide anions. We also report an unusual example of a system exhibiting both a cocrystal and coamorphous form in a halogen bonded lactam model compound with diiodotetrafluorobenzene.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1021/acs.cgd.7b01103
Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01103.
Date accepted:13 September 2017
Date deposited:13 October 2017
Date of first online publication:18 September 2017
Date first made open access:18 September 2018

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