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The role of copper and zinc toxicity in innate immune defense against bacterial pathogens.

Djoko, Karrera Y. and Ong, Cheryl-lynn Y. and Walker, Mark J. and McEwan, Alastair G. (2015) 'The role of copper and zinc toxicity in innate immune defense against bacterial pathogens.', Journal of biological chemistry., 290 (31). pp. 18954-18961.


Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu and/or Zn detoxification systems in phagocytes and animal models of infection has been reported. Consequently, a model has emerged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pathogens. This review describes and assesses the potential role for Cu and Zn intoxication in innate immune function and their direct bactericidal function.

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Publisher statement:This research was originally published in Journal of Biological Chemistry. Karrera Y. Djoko, Cheryl-lynn Y. Ong, Mark J. Walker and Alastair G. McEwan. The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. Journal of Biological Chemistry. 2015. 290: 18954-18961. © the American Society for Biochemistry and Molecular Biology
Date accepted:No date available
Date deposited:17 October 2017
Date of first online publication:08 June 2015
Date first made open access:No date available

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