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Auditory hallucinations and the brain’s resting-state networks : findings and methodological observations.

Alderson-Day, Ben and Diederen, Kelly and Fernyhough, Charles and Ford, Judith M. and Horga, Guillermo and Margulies, Daniel S. and McCarthy-Jones, Simon and Northoff, Georg and Shine, James M. and Turner, Jessica and van de Ven, Vincent and van Lutterveld, Remko and Waters, Flavie and Jardri, Renaud (2016) 'Auditory hallucinations and the brain’s resting-state networks : findings and methodological observations.', Schizophrenia bulletin., 42 (5). pp. 1110-1123.

Abstract

In recent years, there has been increasing interest in the potential for alterations to the brain’s resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1093/schbul/sbw078
Publisher statement:© The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Date accepted:No date available
Date deposited:24 October 2017
Date of first online publication:08 June 2016
Date first made open access:24 October 2017

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