A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, Marcus; Baxendale, Ian R.; Deplante, Fabien

doi:10.3762/bjoc.13.251

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, Marcus; Baxendale, Ian R.; Deplante, Fabien

Authors

Marcus Baumann

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Fabien Deplante

Abstract

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.

Citation

Baumann, M., Baxendale, I. R., & Deplante, F. (2017). A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic. Beilstein Journal of Organic Chemistry, 13, 2549-2560. https://doi.org/10.3762/bjoc.13.251

Journal Article Type	Article
Acceptance Date	Nov 16, 2017
Online Publication Date	Nov 29, 2017
Publication Date	Nov 29, 2017
Deposit Date	Nov 29, 2017
Publicly Available Date	Nov 30, 2017
Journal	Beilstein Journal of Organic Chemistry
Print ISSN	1860-5397
Publisher	Beilstein-Institut
Peer Reviewed	Peer Reviewed
Volume	13
Pages	2549-2560
DOI	https://doi.org/10.3762/bjoc.13.251

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Copyright Statement
© 2017 Baumann et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.