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Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.

Marsh, James W. and Djoko, Karrera Y. and McEwan, Alastair G. and Huston, Wilhelmina M. (2017) 'Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.', Pathogens and disease., 75 (7). ftx084.

Abstract

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1093/femspd/ftx084
Publisher statement:This is a pre-copyedited, author-produced version of an article accepted for publication in Pathogens and Disease following peer review. The version of record James W. Marsh, Karrera Y. Djoko, Alastair G. McEwan, Wilhelmina M. Huston (2017) Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents, Pathogens and Disease, 75(7), ftx084 is available online at: https://doi.org/10.1093/femspd/ftx084.
Date accepted:20 July 2017
Date deposited:21 December 2017
Date of first online publication:24 July 2017
Date first made open access:24 July 2018

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