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Small-molecule povidone analogs in coamorphous pharmaceutical phases.

Goodwin, Melissa and Musa, Osama and Berry, David and Steed, Jonathan W. (2018) 'Small-molecule povidone analogs in coamorphous pharmaceutical phases.', Crystal growth & design., 18 (2). pp. 701-709.

Abstract

The crystallization inhibitor polyvinylpyrrolidone (PVP) is commonly used as a stabilizer in the formation of amorphous polymer dispersions of poorly soluble pharmaceuticals. In this work we examine the use of a range of PVP-inspired small-molecule bis(lactams) as coformers in the stabilization of amorphous pharmaceutical phases creating coamorphous materials. The dimer of N-vinyl(caprolactam) (bisVCap, 3) was found to be an effective coamorphous-former at relatively low loading for carisoprodol, carbamazepine, isoniazid, and 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY).

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1021/acs.cgd.7b01062
Publisher statement:This document is the Accepted Manuscript version of a Published Work that will appear in final form in Crystal growth & design, copyright © American Chemical Society after peer review and technical editing by the publisher.
Date accepted:18 December 2017
Date deposited:05 January 2018
Date of first online publication:04 January 2018
Date first made open access:04 January 2019

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