We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham Research Online
You are in:

Small-molecule povidone analogs in coamorphous pharmaceutical phases.

Goodwin, Melissa and Musa, Osama and Berry, David and Steed, Jonathan W. (2018) 'Small-molecule povidone analogs in coamorphous pharmaceutical phases.', Crystal growth & design., 18 (2). pp. 701-709.


The crystallization inhibitor polyvinylpyrrolidone (PVP) is commonly used as a stabilizer in the formation of amorphous polymer dispersions of poorly soluble pharmaceuticals. In this work we examine the use of a range of PVP-inspired small-molecule bis(lactams) as coformers in the stabilization of amorphous pharmaceutical phases creating coamorphous materials. The dimer of N-vinyl(caprolactam) (bisVCap, 3) was found to be an effective coamorphous-former at relatively low loading for carisoprodol, carbamazepine, isoniazid, and 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY).

Item Type:Article
Full text:(AM) Accepted Manuscript
Download PDF
Publisher Web site:
Publisher statement:This document is the Accepted Manuscript version of a Published Work that will appear in final form in Crystal growth & design, copyright © American Chemical Society after peer review and technical editing by the publisher.
Date accepted:18 December 2017
Date deposited:05 January 2018
Date of first online publication:04 January 2018
Date first made open access:04 January 2019

Save or Share this output

Look up in GoogleScholar