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Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?

Kennedy, Stuart R. and Jones, Christopher D. and Yufit, Dimitrii S. and Nicholson, Catherine Emma and Cooper, Sharon J. and Steed, Jonathan W. (2018) 'Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?', CrystEngComm., 20 (10). pp. 1390-1398.

Abstract

We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1039/C8CE00066B
Date accepted:10 February 2018
Date deposited:13 February 2018
Date of first online publication:12 February 2018
Date first made open access:10 February 2019

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