Professor David Parker david.parker@durham.ac.uk
Emeritus Professor
Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence
Parker, David; Shuvaev, Sergey; Fox, Mark A.
Authors
Sergey Shuvaev
Dr Mark Fox m.a.fox@durham.ac.uk
Assistant Professor
Abstract
A series of three europium complexes is reported bearing picolyl amine moieties with different substituents, that possess differing binding affinities towards Zn2+ and three nucleotides ‐ AMP, ADP and ATP. A large increase of the total emission intensity was observed upon binding Zn2+, followed by further signal amplification upon addition of nucleotides. The resulting adducts possess strong induced circularly polarised emission, with ADP and ATP signals being of opposite sign. Model DFT geometries of the adducts suggest the Δ diastereoisomer is preferred for ATP and the Λ isomer for ADP/AMP. Such a change in sign allows the ADP:/ATP (or AMP/ATP) ratio to be assessed by monitoring changes in the emission dissymmetry factor, gem.
Citation
Parker, D., Shuvaev, S., & Fox, M. A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25), 7488-7492. https://doi.org/10.1002/anie.201801248
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 27, 2018 |
Online Publication Date | Mar 30, 2018 |
Publication Date | Jun 11, 2018 |
Deposit Date | Mar 28, 2018 |
Publicly Available Date | Mar 29, 2024 |
Journal | Angewandte Chemie International Edition |
Print ISSN | 1433-7851 |
Electronic ISSN | 1521-3773 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 57 |
Issue | 25 |
Pages | 7488-7492 |
DOI | https://doi.org/10.1002/anie.201801248 |
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Copyright Statement
This is the accepted version of the following article: Parker, David, Shuvaev, Sergey & Fox, Mark A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25): 7488-7492, which has been published in final form at https://doi.org/10.1002/anie.201801248. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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