Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe

Mosely, Jackie A; Stokes, Peter; Parker, David; Dyer, Philip W; Messinis, Antonis M

doi:10.1177/1469066717732286

Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe

Mosely, Jackie A; Stokes, Peter; Parker, David; Dyer, Philip W; Messinis, Antonis M

Authors

Jackie A Mosely

Peter Stokes peter.stokes@durham.ac.uk
Mass Spectrometry Service Manager

Dr David Parker dave.parker@durham.ac.uk
Experimental Officer

Professor Philip Dyer p.w.dyer@durham.ac.uk
Professor

Antonis M Messinis

Abstract

A novel method has been developed that enables chemical compounds to be transferred from an inert atmosphere glove box and into the atmospheric pressure ion source of a mass spectrometer whilst retaining a controlled chemical environment. This innovative method is simple and cheap to implement on some commercially available mass spectrometers. We have termed this approach inert atmospheric pressure solids analysis probe (iASAP) and demonstrate the benefit of this methodology for two air-/moisture-sensitive chemical compounds whose characterisation by mass spectrometry is now possible and easily achieved. The simplicity of the design means that moving between iASAP and standard ASAP is straightforward and quick, providing a highly flexible platform with rapid sample turnaround.

Citation

Mosely, J. A., Stokes, P., Parker, D., Dyer, P. W., & Messinis, A. M. (2017). Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe. European Journal of Mass Spectrometry, 24(1), 74-80. https://doi.org/10.1177/1469066717732286

Journal Article Type	Article
Acceptance Date	Aug 25, 2017
Online Publication Date	Sep 19, 2017
Publication Date	Sep 19, 2017
Deposit Date	Apr 11, 2018
Publicly Available Date	Apr 11, 2018
Journal	European Journal of Mass Spectrometry
Print ISSN	1469-0667
Electronic ISSN	1751-6838
Publisher	SAGE Publications
Peer Reviewed	Peer Reviewed
Volume	24
Issue	1
Pages	74-80
DOI	https://doi.org/10.1177/1469066717732286

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Copyright Statement
Mosely, Jackie A, Stokes, Peter, Parker, David, Dyer, Philip W & Messinis, Antonis M (2018). Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe. European Journal of Mass Spectrometry 24(1): 74-80. Copyright ©. The Author(s) 2017. Reprinted by permission of SAGE Publications.