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A direct route for the preparation of Fmoc/OtBu protected iodotyrosine.

Steer, A.M. and Bolt, H.L. and Brittain, W.D.G. and Cobb, S.L. (2018) 'A direct route for the preparation of Fmoc/OtBu protected iodotyrosine.', Tetrahedron letters., 59 (27). pp. 2644-2646.

Abstract

Herein the synthesis of an Fmoc/OtBu orthogonally protected iodotyrosine derivative is reported. This has been achieved via a simple two-step process in an overall 58% yield from commercially available Fmoc-Tyr(tBu)-OH. The Fmoc/OtBu orthogonally protected iodotyrosine was also shown to be amenable to Suzuki-Miyaura cross-coupling to deliver a novel bi-aryl tyrosine derivative.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1016/j.tetlet.2018.05.061
Publisher statement:© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Date accepted:22 May 2018
Date deposited:29 May 2018
Date of first online publication:23 May 2018
Date first made open access:No date available

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