Clark, R.I. and Woodcock, K.J. and Geissmann, F. and Trouillet, C. and Dionne, M.S. (2011) 'Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.', Current biology., 21 (19). pp. 1672-1677.
TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals . Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response.
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|Publisher Web site:||https://doi.org/10.1016/j.cub.2011.08.048|
|Publisher statement:||© 2011 Elsevier Ltd. Open access under CC BY license.|
|Date accepted:||19 August 2011|
|Date deposited:||15 June 2018|
|Date of first online publication:||29 September 2011|
|Date first made open access:||No date available|
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