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Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids.

Grigolato, L. and Brittain, W.D.G. and Hudson, A.S. and Czyzewska, M.M and Cobb, S.L (2018) 'Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids.', Journal of fluorine chemistry., 212 . pp. 166-170.


Herein, a series of aromatic pentafluorosulfanyl (SF5) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of Pd(dba)2 and SPhos afforded the aforementioned SF5 amino acids in yields between 32% and 42%. Two dipeptides utilising both the amine and carboxylic functionalities of the synthesised SF5 containing amino acids were prepared, demonstrating their compatibility with common amide/peptide coupling reagents and strategies.

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Publisher statement:© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (
Date accepted:15 June 2018
Date deposited:26 June 2018
Date of first online publication:18 June 2018
Date first made open access:26 June 2018

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