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Synthesis of antibacterial nisin–peptoid hybrids using click methodology.

Bolt, Hannah and Kleijn, Laurens and Martin, Nathaniel and Cobb, Steven (2018) 'Synthesis of antibacterial nisin–peptoid hybrids using click methodology.', Molecules., 23 (7). p. 1566.


Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herein, we have developed a process to prepare novel hybrid antibacterial agents that combine both linear peptoids (increased in vivo stability compared to peptides) and a nisin fragment (lipid II targeting domain). The hybrid nisin–peptoids prepared were shown to have low micromolar activity (comparable to natural nisin) against methicillin-resistant Staphylococcus aureus.

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Publisher statement:© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Date accepted:21 June 2018
Date deposited:12 July 2018
Date of first online publication:28 June 2018
Date first made open access:12 July 2018

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