Flow Synthesis of Coumalic Acid and its Derivatization

Smith, Laura K.; Baxendale, Ian R.

doi:10.1039/c8re00116b

Flow Synthesis of Coumalic Acid and its Derivatization

Smith, Laura K.; Baxendale, Ian R.

Authors

Laura K. Smith

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address with the aid of tubular flow systems and a simple heated rotating flow reactor. The prepared coumalate derivatives can be further used in inverse electron demand Diels-Alder reactions to synthesise compounds with many applications including molecular electronics, with the added advantage of providing metal-free preparations.

Citation

Smith, L. K., & Baxendale, I. R. (2018). Flow Synthesis of Coumalic Acid and its Derivatization. Reaction Chemistry and Engineering, 3(5), 722-732. https://doi.org/10.1039/c8re00116b

Journal Article Type	Article
Acceptance Date	Jul 18, 2018
Online Publication Date	Jul 20, 2018
Publication Date	Oct 1, 2018
Deposit Date	Jul 23, 2018
Publicly Available Date	Jul 18, 2019
Journal	Reaction Chemistry and Engineering
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	3
Issue	5
Pages	722-732
DOI	https://doi.org/10.1039/c8re00116b