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Impact of Electric Fields on the Nanoscale Behavior of Lipid Monolayers at the Surface of Graphite in Solution

Bi, H.; Wang, X.; Han, X.; Voïtchovsky, K.

Impact of Electric Fields on the Nanoscale Behavior of Lipid Monolayers at the Surface of Graphite in Solution Thumbnail


Authors

H. Bi

X. Wang

X. Han



Abstract

The nanoscale organization and dynamics of lipid molecules in self-assembled membranes is central to the biological function of cells and in for the technological development synthetic lipid structures as well as in devices such as biosensors.Here we explore the nanoscale molecular arrangement and dynamics of lipids assembled in monolayers at the surface of highly ordered pyrolytic graphite (HOPG), in different ionic solutions and under electrical potentials. Using a combination of atomic force microscopy and fluorescence recovery after photobleaching, we show that HOPG is able to support fully formed and fluid lipid membranes, but mesoscale order and corrugations can be observed depending on the type of lipid considered (DOPC, DOPS, DOTAP) and the ion present (Na+, Ca2+, Cl-). Interfacial solvation forces and ion-specific effects dominate over the electrostatic changes induced by moderate electric fields (1.0 V versus Ag/AgCl reference electrode) with particularly marked effects in the presence of calcium, and for DOPS. Our results provide insights into the interplay between molecular, ionic and electrostatic interactions and the formation of dynamical ordered structures in fluid lipid membranes.

Citation

Bi, H., Wang, X., Han, X., & Voïtchovsky, K. (2018). Impact of Electric Fields on the Nanoscale Behavior of Lipid Monolayers at the Surface of Graphite in Solution. Langmuir, 34(32), 9561-9571. https://doi.org/10.1021/acs.langmuir.8b01631

Journal Article Type Article
Acceptance Date May 29, 2018
Online Publication Date Jul 20, 2018
Publication Date Aug 14, 2018
Deposit Date Jul 23, 2018
Publicly Available Date Jul 20, 2019
Journal Langmuir
Print ISSN 0743-7463
Electronic ISSN 1520-5827
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 34
Issue 32
Pages 9561-9571
DOI https://doi.org/10.1021/acs.langmuir.8b01631

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Copyright Statement
This is an open access article published under a Creative Commons Attribution (CC-BY)
License, which permits unrestricted use, distribution and reproduction in any medium,
provided the author and source are cited.







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