Simulating Human Cardiac Electrophysiology on Clinical Time-Scales

Plank, Gernot; Smith, Nicolas; Mitchell, Lawrence; Niederer, Steven

doi:10.3389/fphys.2011.00014

Simulating Human Cardiac Electrophysiology on Clinical Time-Scales

Plank, Gernot; Smith, Nicolas; Mitchell, Lawrence; Niederer, Steven

Authors

Gernot Plank

Nicolas Smith

Lawrence Mitchell

Steven Niederer

Abstract

In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.

Citation

Plank, G., Smith, N., Mitchell, L., & Niederer, S. (2011). Simulating Human Cardiac Electrophysiology on Clinical Time-Scales. Frontiers in Physiology, 2, Article 14. https://doi.org/10.3389/fphys.2011.00014

Journal Article Type	Article
Acceptance Date	Mar 26, 2011
Online Publication Date	Apr 9, 2011
Publication Date	Apr 9, 2011
Deposit Date	Aug 1, 2018
Publicly Available Date	Aug 2, 2018
Journal	Frontiers in Physiology
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	2
Article Number	14
DOI	https://doi.org/10.3389/fphys.2011.00014

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Copyright Statement
© 2011 Niederer, Mitchell, Smith and Plank. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.