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Synthesis, crystal structure and DNA/protein binding of tetranuclear Cu(II) complexes with a double-open-cubane like core framework

Paul, Aparup; Puschmann, Horst; Manna, Subal Chandra

Synthesis, crystal structure and DNA/protein binding of tetranuclear Cu(II) complexes with a double-open-cubane like core framework Thumbnail


Authors

Aparup Paul

Subal Chandra Manna



Abstract

The copper(II) complexes [Cu4(L)2(HL)2(H2O)2]∙2(ClO4)∙2(H2O)∙DMF (1) and [Cu4(L)2(HL)2(H2O)2]∙(tp) (2) [H2L = 2-ethoxy-6-[(1-hydroxymethyl-propylimino)-methyl]-phenol; tp = terephthalate] have been synthesized and characterized by single crystal X-ray diffraction and spectroscopic studies. The structural determination reveals that both the complexes are tetranuclear with a double-open-cubane like core framework. The 2D supramolecular structure of 1 and 3D supramolecular structure of 2 are formed through C-H...π and hydrogen bonding interactions, respectively. At room temperature both the complexes exhibit fluorescence with quantum yields of 0.41 and 0.40. The interactions of the complexes with calf thymus DNA (CT-DNA) and serum albumins were investigated using electronic absorption and fluorescence spectroscopic techniques. The studies revels that the binding affinities of 1 and 2 with CT-DNA are of the order 8.86×105 M-1 and 7.14×105 M-1, respectively. Additionally, the interaction of the complexes with bovine serum albumin and human serum albumin were studied and the number of binding sites and binding constants were calculated using a double logarithm regression equation. The redox activities of the complexes were investigated in methanol solution by cyclic voltammetry.

Citation

Paul, A., Puschmann, H., & Manna, S. C. (2018). Synthesis, crystal structure and DNA/protein binding of tetranuclear Cu(II) complexes with a double-open-cubane like core framework. Polyhedron, 155, 447-456. https://doi.org/10.1016/j.poly.2018.08.020

Journal Article Type Article
Acceptance Date Aug 2, 2018
Online Publication Date Aug 17, 2018
Publication Date Nov 15, 2018
Deposit Date Aug 20, 2018
Publicly Available Date Mar 29, 2024
Journal Polyhedron
Print ISSN 0277-5387
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 155
Pages 447-456
DOI https://doi.org/10.1016/j.poly.2018.08.020

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