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Handling of nutrient copper in the bacterial envelope

Stewart, Louisa J.; Thaqi, Denis; Kobe, Bostjan; McEwan, Alastair G.; Waldron, Kevin J.; Djoko, Karrera Y.

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Authors

Louisa J. Stewart

Denis Thaqi

Bostjan Kobe

Alastair G. McEwan

Kevin J. Waldron



Abstract

In bacteria, copper (Cu) is often recognised for its potential toxicity and its antibacterial activity is now considered a key component of the mammalian innate immune system. Cu ions bound in weak sites can catalyse harmful redox reactions while Cu ions in strong but adventitious sites can disrupt protein or enzyme function. For these reasons, the outward transport of Cu from bacteria has received significant attention. Yet, Cu is also a bacterial nutrient, required as a cofactor by enzymes that catalyse electron transfer processes, for instance in aerobic and anaerobic respiration. To date, the inward flow of this metal ion as a nutrient and its insertion into target cuproenzymes remain poorly defined. Here we revisit the available evidence related to bacterial nutrient Cu trafficking and identify gaps in knowledge. Particularly intriguing is the evidence that bacterial cuproenzymes do not always require auxiliary metallochaperones to insert nutrient Cu into their active sites. This review outlines our effort to consolidate the available experimental data using an established energy-driven model for metalation.

Citation

Stewart, L. J., Thaqi, D., Kobe, B., McEwan, A. G., Waldron, K. J., & Djoko, K. Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11(1), 50-63. https://doi.org/10.1039/c8mt00218e

Journal Article Type Article
Acceptance Date Oct 10, 2018
Online Publication Date Oct 10, 2018
Publication Date Jan 1, 2019
Deposit Date Nov 29, 2018
Publicly Available Date Oct 10, 2019
Journal Metallomics
Print ISSN 1756-5901
Electronic ISSN 1756-591X
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Pages 50-63
DOI https://doi.org/10.1039/c8mt00218e

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