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Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle Thousand Families Study

Rudman, Harry; Birrell, Fraser; Pearce, Mark; Tuck, Stephen; Francis, Roger; Hind, Karen

Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle Thousand Families Study Thumbnail


Authors

Harry Rudman

Fraser Birrell

Mark Pearce

Stephen Tuck

Roger Francis

Karen Hind



Abstract

Summary: Obesity increases the likelihood of prevalent vertebral fracture (VF) in men and women at age 62 years. The higher absolute bone mineral density (BMD) observed in obese individuals is disproportionate to body weight, and this may partly explain the greater prevalence of VF in this group. Introduction: Obesity is a global epidemic, and there remains uncertainty over the effect of obesity on skeletal health, particularly in the context of osteoporosis. The aim of this study was to investigate associations of body mass index (BMI) and obesity with BMD and prevalent VF in men and women aged 62 years. Methods: Three hundred and forty-two men and women aged 62.5 ± 0.5 years from the Newcastle Thousand Families Study birth cohort underwent DXA evaluations of femoral neck and lumbar spine BMD and of the lateral spine for vertebral fracture assessment. Results: The likelihood of prevalent VF was significantly increased in men when compared to women (OR = 2.7, p < 0.001, 95% Cl 1.7–4.4). As BMI increased in women, so did the likelihood of prevalent any-grade VF (OR = 1.09, p = 0.006, 95% CI 1.02–1.17). Compared to normal weight women, obese women were more likely to have at least one VF (OR = 2.65, p = 0.025, CI 1.13–6.20) and at least one grade 1 vertebral deformity (OR = 4.39, p = 0.005, CI 1.57–12.28). Obese men were more likely to have a grade 2 and/or grade 3 VF compared to men of normal weight (OR = 3.36, p = 0.032, CI 1.11–10.16). In men and women, BMI was negatively associated with femoral neck BMD/weight (R = − 0.65, R = − 0.66, p < 0.001) and lumbar spine BMD/weight (R = − 0.66, R − 0.60, p < 0.001). Conclusions: Obesity appears to be a risk factor for prevalent VF, and although absolute BMD is higher in obese individuals, this does not appear commensurate to their increased body weight.

Citation

Rudman, H., Birrell, F., Pearce, M., Tuck, S., Francis, R., & Hind, K. (2019). Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle Thousand Families Study. Osteoporosis International, 30(4), 829-836. https://doi.org/10.1007/s00198-018-04817-3

Journal Article Type Article
Acceptance Date Dec 3, 2018
Online Publication Date Jan 8, 2019
Publication Date Apr 30, 2019
Deposit Date Oct 24, 2018
Publicly Available Date Mar 28, 2024
Journal Osteoporosis International
Print ISSN 0937-941X
Electronic ISSN 1433-2965
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 30
Issue 4
Article Number 829-836
Pages 829-836
DOI https://doi.org/10.1007/s00198-018-04817-3

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