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Durham Research Online
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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.

Chisholm, David and Lamb, Rebecca and Pallett, Tommy and Affleck, Valerie and Holden, Claire and Marrison, Joanne and O'Toole, Peter and Ashton, Peter and Newling, Katherine and Steffen, Andreas and Nelson, Amanda and Mahler, Christoph and Valentine, Roy and Blacker, Thomas and Bain, Angus John and Girkin, John M. and Marder, Todd B. and Whiting, Andrew and Ambler, Carrie A. (2019) 'Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.', Chemical science., 10 (17). 4673-4683 .

Abstract

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Available under License - Creative Commons Attribution Non-commercial.
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1039/C9SC00199A
Publisher statement:This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Date accepted:20 March 2019
Date deposited:21 March 2019
Date of first online publication:21 March 2019
Date first made open access:20 March 2020

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