High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Torres-Moya, Iván; Saikia, Basanta; Prieto, Pilar; Carrillo, José R.; Steed, Jonathan W.

doi:10.1039/c8ce01742e

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Torres-Moya, Iván; Saikia, Basanta; Prieto, Pilar; Carrillo, José R.; Steed, Jonathan W.

Authors

Iván Torres-Moya

Basanta Saikia

Pilar Prieto

José R. Carrillo

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Citation

Torres-Moya, I., Saikia, B., Prieto, P., Carrillo, J. R., & Steed, J. W. (2019). High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media. CrystEngComm, 21(13), 2135-2143. https://doi.org/10.1039/c8ce01742e

Journal Article Type	Article
Acceptance Date	Nov 27, 2018
Online Publication Date	Nov 27, 2018
Publication Date	Apr 7, 2019
Deposit Date	Mar 26, 2019
Publicly Available Date	Nov 27, 2019
Journal	CrystEngComm
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	21
Issue	13
Pages	2135-2143
DOI	https://doi.org/10.1039/c8ce01742e