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High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media.

Torres-Moya, Iván and Saikia, Basanta and Prieto, Pilar and Carrillo, José R. and Steed, Jonathan W. (2019) 'High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media.', CrystEngComm., 21 (13). pp. 2135-2143.

Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1039/C8CE01742E
Date accepted:27 November 2018
Date deposited:26 March 2019
Date of first online publication:27 November 2018
Date first made open access:27 November 2019

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