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A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity.

Dragonetti, Claudia and Colombo, Alessia and Fontani, Mattia and Roberto, Dominique and Williams, Gareth and Scotto di Perrotolo, Rossella and Casagrande, Francesca and Barozzi, Sara and Polo, Simona (2019) 'A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity.', Chemistry – a European journal., 25 (33). pp. 7948-7952.

Abstract

Curcumin has chemopreventive properties against a variety of tumours, but it has poor bioavailability. Two new bis‐cyclometallated iridium(III) complexes have been prepared, featuring the natural product curcumin (CUR) or its reduced form, tetrahydrocurcumin (THC), as bidentate, anionic O^O‐binding ligands. The iridium THC complex is highly luminescent in deoxygenated solution and efficiently generates singlet oxygen under aerated conditions, whereas in the curcumin analogue, other non‐radiative decay pathways are competitive. The complexes are rapidly taken up into a variety of human tumour cell lines from solutions of micromolar concentration. They have negligible cytotoxicity in the absence of irradiation. When briefly irradiated by visible light, Ir‐THC becomes highly phototoxic, inducing rapid apoptosis within 2 h. The results show the high potential of such complexes as sensitizers in photodynamic therapy (PDT).

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1002/chem.201901527
Publisher statement:This is the accepted version of the following article: Dragonetti, Claudia, Colombo, Alessia, Fontani, Mattia, Roberto, Dominique, Williams, Gareth, Scotto di Perrotolo, Rossella, Casagrande, Francesca, Barozzi, Sara & Polo, Simona (2019). A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity. Chemistry – A European Journal 25(33): 7948-7952 which has been published in final form at https://doi.org/10.1002/chem.201901527. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Date accepted:15 April 2019
Date deposited:16 April 2019
Date of first online publication:13 May 2019
Date first made open access:13 May 2020

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