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En route to delineating hippocampal roles in spatial learning

Poulter, Steven; Austen, Joseph M.; Kosaki, Yutaka; Dachtler, James; Lever, Colin; McGregor, Anthony

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Authors

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Joseph Austen j.m.austen@durham.ac.uk
PGR Student Doctor of Philosophy

Yutaka Kosaki

James Dachtler



Abstract

The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One theory is that the hippocampus is not required for ‘knowing where’ but rather is crucial in ‘getting there’. To explore this idea in the MWM, we manipulated ‘getting there’ variables, such as passive transport or active swimming towards the hidden platform, in rats with and without hippocampal lesions. Our results suggested that for intact rats, self-motion cues enroute to the hidden goal were a necessary component for ‘place learning’ to progress. Specifically, intact rats could not learn the hidden goal location, when passively transported to it, despite extensive training. However, when rats were either given hippocampal lesions, or placed in a light-tight box during transportation to the hidden goal, passive-placement spatial learning was facilitated. In a subsequent experiment, the ‘getting there’ component of place navigation was simplified, via the placement of two overhead landmarks, one of which served as a beacon. When ‘getting there’ was made easier in this way, hippocampal lesions did not induce deficits in ‘knowing where’ the goal was. In fact, similar to the facilitation observed in passive-placement spatial learning, hippocampal lesions improved landmark learning relative to controls. Finally, demonstrating that our lesions were sufficiently deleterious, hippocampal-lesioned rats were impaired, as predicted, in an environmental-boundary based learning task. We interpret these results in terms of competition between multiple memory systems, and the importance of self-generated motion cues in hippocampal spatial mapping.

Citation

Poulter, S., Austen, J. M., Kosaki, Y., Dachtler, J., Lever, C., & McGregor, A. (2019). En route to delineating hippocampal roles in spatial learning. Behavioural Brain Research, 369, Article 111936. https://doi.org/10.1016/j.bbr.2019.111936

Journal Article Type Article
Acceptance Date May 1, 2019
Online Publication Date May 2, 2019
Publication Date Aug 2, 2019
Deposit Date May 3, 2019
Publicly Available Date Mar 29, 2024
Journal Behavioural Brain Research
Print ISSN 0166-4328
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 369
Article Number 111936
DOI https://doi.org/10.1016/j.bbr.2019.111936

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