Liu, Dongdong and García-López, Víctor and Gunasekera, Richard S. and Greer Nilewski, Lizanne and Alemany, Lawrence B. and Aliyan, Amir and Jin, Tao and Wang, Gufeng and Tour, James M. and Pal, Robert (2019) 'Near infrared light activates molecular nanomachines to drill into and kill cells.', ACS nano., 13 (6). pp. 6813-6823.
Abstract
Using two-photon excitation (2PE), molecular nanomachines (MNMs) are able to drill through cell membranes and kill the cells. This avoids the use of the more damaging ultraviolet (UV) light that has been used formerly to induce this nanomechanical cell-killing effect. Since 2PE is inherently confocal, enormous precision can be realized. The MNMs can be targeted to specific cell surfaces through peptide addends. Further, the efficacy was verified through controlled opening of synthetic bilayer vesicles using the 2PE excitation of MNM that had been trapped within the vesicles.
| Item Type: | Article |
|---|---|
| Full text: | (AM) Accepted Manuscript Download PDF (1078Kb) |
| Status: | Peer-reviewed |
| Publisher Web site: | https://doi.org/10.1021/acsnano.9b01556 |
| Publisher statement: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS nano copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.9b01556 |
| Date accepted: | 21 May 2019 |
| Date deposited: | 24 May 2019 |
| Date of first online publication: | 22 May 2019 |
| Date first made open access: | 22 May 2020 |
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