Liesa Röder
Flow Hydrodediazoniation of Aromatic Heterocycles
Röder, Liesa; Nicholls, Alexander J.; Baxendale, Ian R.
Abstract
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.
Citation
Röder, L., Nicholls, A. J., & Baxendale, I. R. (2019). Flow Hydrodediazoniation of Aromatic Heterocycles. Molecules, 24(10), Article 1996. https://doi.org/10.3390/molecules24101996
Journal Article Type | Article |
---|---|
Acceptance Date | May 22, 2019 |
Online Publication Date | May 24, 2019 |
Publication Date | May 31, 2019 |
Deposit Date | May 24, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | Molecules |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 10 |
Article Number | 1996 |
DOI | https://doi.org/10.3390/molecules24101996 |
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Supplementary information This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Published Journal Article
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Publisher Licence URL
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