Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission

Dai, Lixionh; Zhang, Junhui; Chen, Yuqing; MacKenzie, Lewis E.; Pal, Robert; Law, Ga-Lai

doi:10.1021/acs.inorgchem.9b01799

Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission

Dai, Lixionh; Zhang, Junhui; Chen, Yuqing; MacKenzie, Lewis E.; Pal, Robert; Law, Ga-Lai

Authors

Lixionh Dai

Junhui Zhang

Yuqing Chen

Lewis E. MacKenzie

Professor Robert Pal robert.pal@durham.ac.uk
Professor

Ga-Lai Law

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5– exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (ΔJ = 1) for [TbL3]– and 0.241 (ΔJ = 1) for [TbL4]5– in buffer solutions were recorded.

Citation

Dai, L., Zhang, J., Chen, Y., MacKenzie, L. E., Pal, R., & Law, G. (2019). Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission. Inorganic Chemistry, 58(19), 12506-12510. https://doi.org/10.1021/acs.inorgchem.9b01799

Journal Article Type	Article
Acceptance Date	Aug 26, 2019
Online Publication Date	Sep 6, 2019
Publication Date	Oct 7, 2019
Deposit Date	Aug 28, 2019
Publicly Available Date	Sep 6, 2020
Journal	Inorganic Chemistry
Print ISSN	0020-1669
Electronic ISSN	1520-510X
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	58
Issue	19
Pages	12506-12510
DOI	https://doi.org/10.1021/acs.inorgchem.9b01799

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.inorgchem.9b01799