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The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects

Leitch, Alistair C.; Abdelghany, Tarek M.; Probert, Philip M.; Dunn, Michael P.; Meyer, Stephanie K.; Palmer, Jeremy M.; Cooke, Martin P.; Blake, Lynsay I.; Morse, Katie; Rosenmai, Anna K.; Oskarsson, Agneta; Bates, Lucy; Figueiredo, Rodrigo S.; Ibrahim, Ibrahim; Wilson, Colin; Abdelkader, Noha F.; Jones, David E.; Blain, Peter G.; Wright, Matthew C.

The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects Thumbnail


Authors

Alistair C. Leitch

Tarek M. Abdelghany

Philip M. Probert

Michael P. Dunn

Stephanie K. Meyer

Jeremy M. Palmer

Martin P. Cooke

Lynsay I. Blake

Katie Morse

Anna K. Rosenmai

Agneta Oskarsson

Lucy Bates

Rodrigo S. Figueiredo

Ibrahim Ibrahim

Colin Wilson

Noha F. Abdelkader

David E. Jones

Peter G. Blain

Matthew C. Wright



Abstract

Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) – an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid – to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.

Citation

Leitch, A. C., Abdelghany, T. M., Probert, P. M., Dunn, M. P., Meyer, S. K., Palmer, J. M., …Wright, M. C. (2020). The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food and Chemical Toxicology, 136, Article 111069. https://doi.org/10.1016/j.fct.2019.111069

Journal Article Type Article
Acceptance Date Dec 19, 2019
Online Publication Date Dec 27, 2019
Publication Date Feb 28, 2020
Deposit Date Jan 2, 2020
Publicly Available Date Jan 2, 2020
Journal Food and Chemical Toxicology
Print ISSN 0278-6915
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 136
Article Number 111069
DOI https://doi.org/10.1016/j.fct.2019.111069

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