Alistair C. Leitch
The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects
Leitch, Alistair C.; Abdelghany, Tarek M.; Probert, Philip M.; Dunn, Michael P.; Meyer, Stephanie K.; Palmer, Jeremy M.; Cooke, Martin P.; Blake, Lynsay I.; Morse, Katie; Rosenmai, Anna K.; Oskarsson, Agneta; Bates, Lucy; Figueiredo, Rodrigo S.; Ibrahim, Ibrahim; Wilson, Colin; Abdelkader, Noha F.; Jones, David E.; Blain, Peter G.; Wright, Matthew C.
Authors
Tarek M. Abdelghany
Philip M. Probert
Michael P. Dunn
Stephanie K. Meyer
Jeremy M. Palmer
Martin P. Cooke
Lynsay I. Blake
Katie Morse
Anna K. Rosenmai
Agneta Oskarsson
Lucy Bates
Rodrigo S. Figueiredo
Ibrahim Ibrahim
Colin Wilson
Noha F. Abdelkader
David E. Jones
Peter G. Blain
Matthew C. Wright
Abstract
Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) – an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid – to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.
Citation
Leitch, A. C., Abdelghany, T. M., Probert, P. M., Dunn, M. P., Meyer, S. K., Palmer, J. M., …Wright, M. C. (2020). The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food and Chemical Toxicology, 136, Article 111069. https://doi.org/10.1016/j.fct.2019.111069
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 19, 2019 |
Online Publication Date | Dec 27, 2019 |
Publication Date | Feb 28, 2020 |
Deposit Date | Jan 2, 2020 |
Publicly Available Date | Jan 2, 2020 |
Journal | Food and Chemical Toxicology |
Print ISSN | 0278-6915 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 136 |
Article Number | 111069 |
DOI | https://doi.org/10.1016/j.fct.2019.111069 |
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Copyright Statement
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)
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