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Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells

Ayala Orozco, Ciceron; Liu, Dongdong; Li, Yongjiang; Alemany, Lawrence B.; Pal, Robert; Krishnan, Sunil; Tour, James M.

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Authors

Ciceron Ayala Orozco

Dongdong Liu

Yongjiang Li

Lawrence B. Alemany

Sunil Krishnan

James M. Tour



Abstract

Recently, synthetic molecular nanomachines (MNMs) that rotate unidirectionally in response to UV light excitation have been used to produce nanomechanical action on live cells to kill them through the drilling of holes in their cell membranes. In the work here, visible-light-absorbing MNMs are designed and synthesized to enable nanomechanical activation by 405 nm light, thereby using a wavelength of light that is less phototoxic than the previously employed UV wavelengths. Visible-light-absorbing MNMs that kill pancreatic cancer cells upon response to light activation are demonstrated. Evidence is presented to support the conclusion that MNMs do not kill cancer cells by the photothermal effect when used at low optical density. In addition, MNMs suppress the formation of reactive oxygen species, leaving nanomechanical action as the most plausible working mechanism for cell killing under the experimental conditions.

Citation

Ayala Orozco, C., Liu, D., Li, Y., Alemany, L. B., Pal, R., Krishnan, S., & Tour, J. M. (2020). Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells. ACS Applied Materials and Interfaces, 12(1), 410-417. https://doi.org/10.1021/acsami.9b21497

Journal Article Type Article
Acceptance Date Dec 9, 2019
Online Publication Date Dec 9, 2019
Publication Date Jan 8, 2020
Deposit Date Jan 10, 2020
Publicly Available Date Dec 9, 2020
Journal ACS Applied Materials and Interfaces
Print ISSN 1944-8244
Electronic ISSN 1944-8252
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Pages 410-417
DOI https://doi.org/10.1021/acsami.9b21497

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS applied materials & interfaces copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.9b21497





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