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Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.

Davies, Tim and Kim, Han X. and Romano Spica, Natalia and Lesea-Pringle, Benjamin J. and Dumont, Julien and Shirasu-Hiza, Mimi and Canman, Julie C. (2018) 'Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.', eLife., 7 . e36204.

Abstract

Cytokinesis, the physical division of one cell into two, is powered by constriction of an actomyosin contractile ring. It has long been assumed that all animal cells divide by a similar molecular mechanism, but growing evidence suggests that cytokinetic regulation in individual cell types has more variation than previously realized. In the four-cell Caenorhabditis elegans embryo, each blastomere has a distinct cell fate, specified by conserved pathways. Using fast-acting temperature-sensitive mutants and acute drug treatment, we identified cell-type-specific variation in the cytokinetic requirement for a robust forminCYK-1-dependent filamentous-actin (F-actin) cytoskeleton. In one cell (P2), this cytokinetic variation is cell-intrinsically regulated, whereas in another cell (EMS) this variation is cell-extrinsically regulated, dependent on both SrcSRC-1 signaling and direct contact with its neighbor cell, P2. Thus, both cell-intrinsic and -extrinsic mechanisms control cytokinetic variation in individual cell types and can protect against division failure when the contractile ring is weakened.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.7554/eLife.36204
Publisher statement:© 2018, Davies et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Date accepted:10 June 2018
Date deposited:16 February 2020
Date of first online publication:20 July 2018
Date first made open access:16 February 2020

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