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Organization of olfactory centres in the malaria mosquito Anopheles gambiae.

Riabinina, O. and Task, D. and Marr, E. and Lin, C.-C. and Alford, R. and O'Brochta, D. A. and Potter, C. J. (2016) 'Organization of olfactory centres in the malaria mosquito Anopheles gambiae.', Nature communications., 7 (1). p. 13010.

Abstract

Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the circuitry underlying sensory signalling in the mosquito brain is lacking. Here we used the Q-system of binary gene expression to develop transgenic lines of Anopheles gambiae in which olfactory receptor neurons expressing the odorant receptor co-receptor (Orco) gene are labelled with GFP. These neurons project from the antennae and maxillary palps to the antennal lobe (AL) and from the labella on the proboscis to the suboesophageal zone (SEZ), suggesting integration of olfactory and gustatory signals occurs in this brain region. We present detailed anatomical maps of olfactory innervations in the AL and the SEZ, identifying glomeruli that may respond to human body odours or carbon dioxide. Our results pave the way for anatomical and functional neurogenetic studies of sensory processing in mosquitoes.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1038/ncomms13010
Publisher statement:This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Date accepted:25 August 2016
Date deposited:05 March 2020
Date of first online publication:03 October 2016
Date first made open access:05 March 2020

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