Meksawangwong, Sureemas and Gohil, Bhavini and Punyain, Wikorn and Pal, Robert and Kielar, Filip (2020) 'Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification.', Inorganica chimica acta., 508 . p. 119609.
Abstract
Herein we report the synthesis and investigation of two novel tris-cyclometalated iridium complexes derived from [Ir(ppy)3] and bearing an aminoalkyl substituent on one of the 2-phenylpyridine ligands. These complexes differ in the number of the alkyl substituents of the aminoalkyl group. Specifically, the complexes reported herein contain one (1) and two (2) 2-hydroxy ethyl groups on the nitrogen atom. Both complexes retain the good photophysical properties reported for earlier versions of this group of tris-cyclometalated iridium complexes. However, the differences in the substitution results in changes in the responsive photoluminescence behavior in aqueous solutions. Live cell microscopy experiments revealed that complexes can localize in NIH-3T3 cells. Finally, it has been observed that the complex containing two 2-hydroxy ethyl groups is less cytotoxic than the it’s mono-substituted counterpart
| Item Type: | Article |
|---|---|
| Full text: | (AM) Accepted Manuscript Available under License - Creative Commons Attribution Non-commercial No Derivatives. Download PDF (1464Kb) |
| Status: | Peer-reviewed |
| Publisher Web site: | https://doi.org/10.1016/j.ica.2020.119609 |
| Publisher statement: | © 2020 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Date accepted: | 19 March 2020 |
| Date deposited: | 22 March 2020 |
| Date of first online publication: | 20 March 2020 |
| Date first made open access: | 20 March 2021 |
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