Mehdi Sharifi-Rad
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
Sharifi-Rad, Mehdi; Lankatillake, Chintha; Dias, Daniel A.; Docea, Anca Oana; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Chazot, Paul L.; Kurt, Begum; Boyunegmez Tumer, Tugba; Catarina Moreira, Ana; Sharopov, Farukh; Martorell, Miquel; Martins, Natália; Cho, William C.; Calina, Daniela; Sharifi-Rad, Javad
Authors
Chintha Lankatillake
Daniel A. Dias
Anca Oana Docea
Mohamad Fawzi Mahomoodally
Devina Lobine
Professor Paul Chazot paul.chazot@durham.ac.uk
Professor
Begum Kurt
Tugba Boyunegmez Tumer
Ana Catarina Moreira
Farukh Sharopov
Miquel Martorell
Natália Martins
William C. Cho
Daniela Calina
Javad Sharifi-Rad
Abstract
Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.
Citation
Sharifi-Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., …Sharifi-Rad, J. (2020). Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. Journal of Clinical Medicine, 9(4), Article 1061. https://doi.org/10.3390/jcm9041061
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Apr 3, 2020 |
| Online Publication Date | Apr 8, 2020 |
| Publication Date | Apr 30, 2020 |
| Deposit Date | May 12, 2020 |
| Publicly Available Date | May 12, 2020 |
| Journal | Journal of Clinical Medicine |
| Publisher | MDPI |
| Peer Reviewed | Peer Reviewed |
| Volume | 9 |
| Issue | 4 |
| Article Number | 1061 |
| DOI | https://doi.org/10.3390/jcm9041061 |
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Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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