We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham Research Online
You are in:

Impact of natural compounds on neurodegenerative disorders : from preclinical to pharmacotherapeutics.

Sharifi-Rad, Mehdi and Lankatillake, Chintha and Dias, Daniel A. and Docea, Anca Oana and Mahomoodally, Mohamad Fawzi and Lobine, Devina and Chazot, Paul L. and Kurt, Begum and Boyunegmez Tumer, Tugba and Catarina Moreira, Ana and Sharopov, Farukh and Martorell, Miquel and Martins, Natália and Cho, William C. and Calina, Daniela and Sharifi-Rad, Javad (2020) 'Impact of natural compounds on neurodegenerative disorders : from preclinical to pharmacotherapeutics.', Journal of clinical medicine., 9 (4). p. 1061.


Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

Item Type:Article
Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution.
Download PDF
Publisher Web site:
Publisher statement:© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Date accepted:03 April 2020
Date deposited:12 May 2020
Date of first online publication:08 April 2020
Date first made open access:12 May 2020

Save or Share this output

Look up in GoogleScholar