A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Gambacorta, Guido; Apperley, David C.; Baxendale, Ian R.

doi:10.3390/molecules25092160

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Gambacorta, Guido; Apperley, David C.; Baxendale, Ian R.

Authors

Guido Gambacorta

David C. Apperley

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Citation

Gambacorta, G., Apperley, D. C., & Baxendale, I. R. (2020). A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives. Molecules, 25(9), Article 2160. https://doi.org/10.3390/molecules25092160

Journal Article Type	Article
Acceptance Date	Apr 30, 2020
Online Publication Date	May 5, 2020
Publication Date	May 1, 2020
Deposit Date	May 27, 2020
Publicly Available Date	May 27, 2020
Journal	Molecules
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	25
Issue	9
Article Number	2160
DOI	https://doi.org/10.3390/molecules25092160

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