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Associations of muscle size and density with proximal femur bone in a community dwelling older population

Yin, Lu; Xu, Zhengyang; Wang, Ling; Li, Wei; Zhao, Yue; Su, Yongbin; Sun, Wei; Liu, Yangdong; Yang, Mingbui; Yu, Aibong; Blake, Glen M; Wu, Xingbao; Veldhuis-Vlug, Annegreet; Cheng, Xiaoguang; Hind, Karen; Engelke, Klaus

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Authors

Lu Yin

Zhengyang Xu

Ling Wang

Wei Li

Yue Zhao

Yongbin Su

Wei Sun

Yangdong Liu

Mingbui Yang

Aibong Yu

Glen M Blake

Xingbao Wu

Annegreet Veldhuis-Vlug

Xiaoguang Cheng

Karen Hind

Klaus Engelke



Abstract

Background and Purpose: Muscle weakness and bone fragility are both associated with hip fracture. In general, muscle contractions create forces to the bone, and bone strength adapts to mechanical loading through changes in bone architecture and mass. However, the relationship between impairment of muscle and bone function remain unclear. In particular, the associations of muscle with properties of proximal femur cortical and trabecular bone are still not well understood. The aim of this study was to explore the associations of hip/thigh muscle density (CT attenuation value in Hounsfield units) and size with cortical and trabecular bone mineral density (BMD) of the proximal femur. Materials and Methods: Three-dimensional quantitative computed tomography (QCT) imaging of the lumber, hip and mid-thigh was performed in a total of 301 participants (mean age 68.4 ± 6.1 years, 194 women and 107 men) to derive areal BMD (aBMD) and volumetric BMD (vBMD). Handgrip strength (HGS) and the Timed Up and Go (TUG) test were also performed. From the CT images, cross-sectional area (CSA), and density were determined for the gluteus maximus muscle (G.MaxM), trunk muscle at the vertebrae L2 level, and mid-thigh muscle. Multivariate generalized linear models were applied to assess associations. Results: Total hip (TH) aBMD was associated significantly with G.MaxM CSA (men: P = 0.042; women: P < 0.001) and density (men: P = 0.012; women: P = 0.043). In women, 0.035 cm2 of mid-thigh CSA (95% CI, 0.014–0.057; P = 0.002) increased per SD increase in TH aBMD, but this significance was not observed in men (P = 0.095). Trunk muscle density and CSA were not associated with proximal femur BMD. The associations of hip/thigh muscle parameters with femoral neck BMD were weaker than those with trochanter and intertrochanter BMD. Furthermore, compared to muscle density, muscle CSA showed better associations with vBMD. G.MaxM CSA was associated with trochanter (TR) Cort. vBMD in men (β, 19.898; 95% CI, 0.924–38.871; P = 0.040) and in women (β, 15.426; 95% CI, 0.893–29.958; P = 0.038). Handgrip strength was only associated with TR aBMD (β, 0.038; 95% CI, 0.006–0.070; P = 0.019) and intertrochanter aBMD (β, 0.049; 95% CI, 0.009–0.090; P = 0.016) in men. Conclusions: We observed positive associations of the gluteus and thigh muscle size with proximal femur volumetric BMD. Specifically, the gluteus maximus muscle CSA was associated with trochanter cortical vBMD in both men and women.

Citation

Yin, L., Xu, Z., Wang, L., Li, W., Zhao, Y., Su, Y., …Engelke, K. (2020). Associations of muscle size and density with proximal femur bone in a community dwelling older population. Frontiers in Endocrinology, 11, Article 503. https://doi.org/10.3389/fendo.2020.00503

Journal Article Type Article
Acceptance Date Jun 23, 2020
Online Publication Date Jul 28, 2020
Publication Date 2020
Deposit Date Jul 8, 2020
Publicly Available Date Mar 29, 2024
Journal Frontiers in Endocrinology
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 503
DOI https://doi.org/10.3389/fendo.2020.00503

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright: © 2020 Yin, Xu, Wang, Li, Zhao, Su, Sun, Liu, Yang, Yu, Blake, Wu, Veldhuis-Vlug, Cheng, Hind and Engelke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.




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