Tyler, Andrew R. and Ragbirsingh, Ronnie and McMonagle, Charles J. and Waddell, Paul G. and Heaps, Sarah E. and Steed, Jonathan W. and Thaw, Paul and Hall, Michael J. and Probert, Michael R. (2020) 'Encapsulated nanodroplet crystallization of organic-soluble small molecules.', Chem., 6 (7). pp. 1755-1765.
Small molecules can form crystalline solids, in which individual molecules pack together into ordered three-dimensional arrays. Once a suitable crystal is grown, the packing and atomic connectivity of the constituent molecules can be studied by X-ray diffraction. However, the discovery of experimental conditions for successful crystal growth is often challenging. We have developed a nanoscale crystallization technique for organic-soluble small molecules by using high-throughput liquid-handling robotics to undertake multiple crystallization experiments simultaneously with minimal sample requirements and high success rates. We showcase our methodology through the crystallization of a diverse set of small molecules, including “uncrystallizables,” combined with structural analysis by X-ray diffraction. We anticipate that this rapid and reliable method for small-molecule crystallization will have far-reaching impact, facilitating academic and industrial research in the molecular sciences.
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|Publisher Web site:||https://doi.org/10.1016/j.chempr.2020.04.009|
|Publisher statement:||This article was published under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence.|
|Date accepted:||15 April 2020|
|Date deposited:||15 July 2020|
|Date of first online publication:||09 July 2020|
|Date first made open access:||15 July 2020|
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