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Real time monitoring of interactions of gold nanoparticles with supported phospholipid lipid layers

Bunga, Yousillya; Kataky, Ritu

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Authors

Yousillya Bunga



Abstract

Rapid methods for assessing engineered nanoparticle (NP) and their interactions with lipid membranes is important to several fields including pharmaceutical, clinical and toxicological studies. This study presents Resonance Enhanced Surface Impedance spectroscopy (RESI) as a method for real time assessment of NP interactions. RESI, used in a flow-injection analysis mode, provides a rapid and versatile method for revealing lipid disruption and reorganisation. Ferrocenated gold NPs (FcHT-AuNP) of three different sizes, were used to study their interactions with supported lipid layers. Electrochemistry and Atomic Force Microscopy (AFM) was used to complement RESI results, showing, that with increased incubation, AuNPs tend to agglomerate on the substrate. The effect of the change in hydrophilicity of the FcHT-AuNP upon oxidation, was immediately evident, using RESI, giving direct evidence that in its ferrocenium form the NPs tend to resist lipid adsorption.

Citation

Bunga, Y., & Kataky, R. (2020). Real time monitoring of interactions of gold nanoparticles with supported phospholipid lipid layers. Journal of Electroanalytical Chemistry, 872, Article 114302. https://doi.org/10.1016/j.jelechem.2020.114302

Journal Article Type Article
Acceptance Date May 24, 2020
Online Publication Date Jun 11, 2020
Publication Date 2020-09
Deposit Date Jul 21, 2020
Publicly Available Date Jun 11, 2021
Journal Journal of Electroanalytical Chemistry
Print ISSN 1572-6657
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 872
Article Number 114302
DOI https://doi.org/10.1016/j.jelechem.2020.114302

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