Jackson, Samuel E. and Vernon, Ian and Liu, Junli and Lindsey, Keith (2020) 'Understanding hormonal crosstalk in Arabidopsis root development via emulation and history matching.', Statistical applications in genetics and molecular biology., 19 (2). p. 20180053.
A major challenge in plant developmental biology is to understand how plant growth is coordinated by interacting hormones and genes. To meet this challenge, it is important to not only use experimental data, but also formulate a mathematical model. For the mathematical model to best describe the true biological system, it is necessary to understand the parameter space of the model, along with the links between the model, the parameter space and experimental observations. We develop sequential history matching methodology, using Bayesian emulation, to gain substantial insight into biological model parameter spaces. This is achieved by finding sets of acceptable parameters in accordance with successive sets of physical observations. These methods are then applied to a complex hormonal crosstalk model for Arabidopsis root growth. In this application, we demonstrate how an initial set of 22 observed trends reduce the volume of the set of acceptable inputs to a proportion of 6.1 × 10−7 of the original space. Additional sets of biologically relevant experimental data, each of size 5, reduce the size of this space by a further three and two orders of magnitude respectively. Hence, we provide insight into the constraints placed upon the model structure by, and the biological consequences of, measuring subsets of observations.
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|Publisher Web site:||https://doi.org/10.1515/sagmb-2018-0053|
|Publisher statement:||The final publication is available at www.degruyter.com|
|Date accepted:||12 May 2020|
|Date deposited:||05 August 2020|
|Date of first online publication:||13 July 2020|
|Date first made open access:||13 July 2021|
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