Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

Lopera, Alberto; Aguilar, Juan A.; Belda, Raquel; Verdejo, Begoña; Steed, Jonathan W.; García-España, Enrique

doi:10.1039/d0sm00704h

Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

Lopera, Alberto; Aguilar, Juan A.; Belda, Raquel; Verdejo, Begoña; Steed, Jonathan W.; García-España, Enrique

Authors

Alberto Lopera

Juan A. Aguilar

Raquel Belda

Begoña Verdejo

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Enrique García-España

Abstract

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

Citation

Lopera, A., Aguilar, J. A., Belda, R., Verdejo, B., Steed, J. W., & García-España, E. (2020). Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation. Soft Matter, 16(28), 6514-6522. https://doi.org/10.1039/d0sm00704h

Journal Article Type	Article
Acceptance Date	Jun 9, 2020
Online Publication Date	Jun 10, 2020
Publication Date	2020-07
Deposit Date	Aug 6, 2020
Publicly Available Date	Jun 9, 2021
Journal	Soft Matter
Print ISSN	1744-683X
Electronic ISSN	1744-6848
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	16
Issue	28
Pages	6514-6522
DOI	https://doi.org/10.1039/d0sm00704h